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'Housekeepers' of the brain renew themselves more quickly than first thought

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Microglia cells (inexperienced spider shapes). Credit score: Picture courtesy of College of Southampton Cells within the mind accountable for detecting and fixing minor injury renew themselves extra rapidly than beforehand thought, new analysis has proven. A research, led by the College of Southampton and printed in Cell Experiences, exhibits that the turnover of the cells, known as Microglia, is 10 occasions sooner, permitting the entire inhabitants of Microglia cells to be renewed a number of occasions throughout a lifetime. "Microglia are consistently scanning the mind to search out and repair points -- you may name them the housekeepers of the mind," stated Dr Diego Gomez-Nicola, of the College of Southampton, who supervised the research. "We beforehand thought that microglia would renew themselves so slowly that an entire lifetim...

New molecular discovery may help identify drug therapies to prevent dementia

"Memory decline brings much suffering to the affected individuals and their families and leads to staggering social and economic costs," said Gleb Shumyatsky, an associate professor in the Department of Genetics in the School of Arts and Sciences, who co-authored the study with former postdoctoral researcher Shusaku Uchida. "This work may provide scientists with answers and therapeutic help in the future for those going through normal aging or suffering from dementia." The research published on January 10 in  Cell Reports  focuses on the signaling pathways in the hippocampus, the area of the brain where learning and memory takes place. The scientists looked at how information is transmitted from the synapses -- the point where neurons connect and communicate with each other -- to the nuclei in the hippocampal neuronal cells. Using laboratory mice, researchers found that a protein (CRTC1) enhances memory by controlling gene expression -- a process that allow...

Rural dementia: We need to talk

The year-long study was undertaken by Dr Claire Kelly and Dr Richard Yarwood from the School of Geography, Earth and Environmental Sciences at Plymouth University with support from Ian Sherriff, Academic Partnership Lead for Dementia at the University and Chair of the Prime Minister's Rural Dementia Friendly Task and Finish Group. It was funded by the Seale Hayne Educational Trust with support from the Farming Community Network . The four areas of concern identified by the study were: the farm environment; a reluctance to ask for help; support services, and; changing rural communities. The areas of concern emerged after listening to farmers and their families about their experiences of dementia and how it impacts on their business and home lives. Sixteen farmers from across Devon were interviewed, along with seven professionals from different organisational perspectives working with, and supporting, farmers living with dementia. Concerns about the farm environment related...