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The findings, published in the  Journal of Alzheimer's Disease , shed new light on the relationship between genes, lifestyle risk factors and dementia. Researchers, who tracked participants in the Canadian Study of Health and Aging, found that while carriers of a variant of the 'apolipoprotein E' genotype are more likely to develop dementia, inactivity dramatically increases the risk for non-carriers. "The important message here is that being inactive may completely negate the protective effects of a healthy set of genes," says Jennifer Heisz, an assistant professor in the Department of Kinesiology at McMaster University and co-author of the study. "Given that most individuals are not at genetic risk, physical exercise may be an effective prevention strategy, " she says. Approximately 47.5-million people worldwide are living with dementia . That number is expected to surge to 115.4 million by the year 2050. With no known cure, there is an ur...

"Chicoric acid, a nutraceutical component of chicory, also exists extensively in Echinacea purpurea, lettuce, dandelion, and other edible plants and vegetables," said Xuebo Liu, Ph.D., a researcher involved in the work at the College of Food Science and Engineering, Northwest A&F University, in Yangling, China. "Chicoric acid mitigated lipopolysaccharide-induced amyloidogenesis and memory impairment via inhibiting NF?B signal pathway, suggesting that chicoric acid supplementation might be a plausible therapeutic intervention for neuroinflammation-related diseases such as Alzheimer's disease." To reach their conclusions, Liu and colleagues used three groups of mice: a control group, a group that received lipopolysaccharide (LPS), and another group that received both LPS and chicoric acid (CA). Learning and memory capabilities were evaluated using two separate behavioral tests (Y-maze and Morris water maze) four hours after LPS injection. They found that t...